People: W. Krassowska Neu, K. Skuibine

Collaborators: S. Knisley (UA Birmingham), B. Roth (Oakland Univ.), N. Trayanova (Tulane)

Additional information: Dr. Kirill Skouibine Web Page

Key Publications:

W. Krassowska, Field stimulation of cardiac fibers with random spatial structure, IEEE Trans. Biomed. Eng., submitted.

K. Skouibine and W. Krassowska, Increasing computational efficiency of a bidomain model of defibrillation using time-dependent activating function, Ann. Biomed. Eng., 28: 772-780, 2000.

B. J. Roth and W. Krassowska, The induction of reentry in cardiac tissue. The missing link: How electric fields alter transmembrane potential, Chaos, 8: 204-220, 1998

W. Krassowska, Modeling the interaction of cardiac muscle with strong fields, in Case Studies in Mathematical Modeling--Ecology, Physiology and Biofluids, edited by Hans G. Othmer, Fred R. Adler, Mark A. Lewis and J. C. Dallon, Prentice Hall, Upper Saddle River, NJ. pp. 277-308, 1997

R. E. Ideker, David W. Frazier. W. Krassowska and J. Marcus Wharton, Physiologic effects of electrical stimulation in cardiac muscle, in The Electrical Therapy of Cardiac Arrhythmias, edited by S. Saksena and N. Goldschlager, W. B. Saunders, Philadelphia, PA, pp. 357-370, 1990

Support: NSF Grants BES-9409026, CDR-8622201, NIH Grant HL54071, and GIG Grant DMS 97-09608

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People: W. Krassowska Neu, K. Skuibine

Collaborators: S. Knisley (UA Birmingham), B. Roth (Oakland Univ.), N. Trayanova (Tulane)

Additional information: Dr. Kirill Skouibine Web Page

Key Publications:

K. Skouibine, J. Wall, W. Krassowska, and N. A. Trayanova, Modeling induction of a rotor in cardiac muscle by perpendicular electric shocks Med. Biol. Eng. Comput., 40: 47-55,2002.

B. J. Roth and W. Krassowska, The induction of reentry in cardiac tissue. The missing link: How electric fields alter transmembrane potential, Chaos, 8: 204-220, 1998

W. Krassowska and M. S. Kumar, The role of spatial interactions in creating the dispersion of transmembrane potential by premature electric shocks, Ann. Biomed. Eng., 25: 949-963, 1997

Support: NIH Grant HL54071, NSF Grant CDR-8622201, and GIG Grant DMS 97-09608

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People: K. DeBruin, W. Krassowska Neu, K. Skuibine

Collaborators: N. Trayanova (Tulane)

Key Publications:

F. Aguel, K. A. DeBruin, W. Krassowska and N. Trayanova, Effects of electroporation on the transmembrane potential distribution in a two-dimensional bidomain model of cardiac tissue, J. Cardiovasc. Electrophysiol., 10: 701-714, 1999

K. A. DeBruin and W. Krassowska, Electroporation and shock-induced transmembrane potential in a cardiac strand during defibrillation strength shocks, Ann. Biomed. Eng., 26: 584-596, 1998

W. Krassowska, Effects of electroporation on transmembrane potential induced by defibrillation shocks, PACE, 18: 1644-1660, 1995

Support: NIH Grant HL54071 and NSF Grant CDR-8622201

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People: W. Krassowska Neu

Collaborators: J. Neu (UC Berkeley)

Key Publications:

W. Krassowska and J. C. Neu, Effective boundary conditions for syncytial tissues, IEEE Trans. Biomed. Eng., 41: 143-150, 1994

J. C. Neu and W. Krassowska, Homogenization of syncytial tissues, CRC Crit. Rev. Biomed. Eng., 21: 137-199, 1993

W. Krassowska, T. C. Pilkington and R. E. Ideker, Potential distribution in three-dimensional periodic myocardium: Part I. Solution with two-scale asymptotic analysis, IEEE Trans. Biomed. Eng., 37: 252-266, 1990

Support: NIH Grants HL40092, HL28429, HL33637, HL17670, NSF Grant CDR-8622201, and the Whitaker Foundation

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People: W. Krassowska Neu, B. Stone

Collaborators: J. Neu (UC Berkeley), M. Lieberman (Duke, Cell Biology)

Key Publications:

W. Krassowska, B. A. Stone, and J. C. Neu, Electrical stimulation of cardiac cells. In "Quantitative Cardiac Electrophysiology", C. Cabo and D. S. Rosenbaum, Eds., Marcel Dekker, Inc., New York, NY, pp. 139-197, in press.

B. A. Stone, M. Lieberman and W. Krassowska, Field stimulation of isolated chick heart cells: Comparison of experimental and theoretical activation thresholds, J. Cardiovasc. Electrophysiol., 10: 92-107, 1999

W. Krassowska and J. C. Neu, Response of a single cell to an external electric field, Biophys. J., 66: 1768-1776, 1994

Support: NIH Grant HL207105, NSF Grants BES-9409026 and CDR-8622201

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People: W. Krassowska Neu

Collaborators: R. Ideker, T. Pilkington

Key Publications:

W. Krassowska, T. C. Pilkington and R. E. Ideker, Two-scale asymptotic analysis for modeling activation of a periodic cardiac strand, Mathl. Comput. Modelling, 16: 121-130, 1992

W. Krassowska, T. C. Pilkington and R. E. Ideker, The closed form solution to the periodic core-conductor model using asymptotic analysis, IEEE Trans. Biomed. Eng., 34: 519-531, 1987

Support: NIH Grants HL40092, HL28429, HL33637, HL17670 and HL11307, and NSF Grant CDR-8622201

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People: W. Krassowska Neu, R.S. Preissig

Collaborators: J. Neu (UC Berkeley), C. Cabo, S. B. Knisley, R. Ideker, T. Pilkington, P. Wolf

Key Publications:

J. C. Neu, R. S. Preissig, Jr. and W. Krassowska, Initiation of propagation in a one-dimensional excitable medium, Physica D, 102: 285-299, 1997

W. Krassowska, D.L. Rollins, P.D. Wolf, E.G. Dixon, T. C. Pilkington and R. E. Ideker, Pacing thresholds for cathodal and anodal high-frequency monophasic pulses, J. Cardiovasc. Electrophysiol., 3: 64-76, 1992

W. Krassowska, C. Cabo, S. B. Knisley and R. E. Ideker, Propagation versus delayed activation during field stimulation of cardiac muscle, PACE, 15: 197-210, 1992

Support: NSF Grants BES-9409026 and CDR-8622201, NIH Grants HL54071, HL40092, HL28429, HL33637, HL44066 and HL42760, the Whitaker Foundation, and the Thomas Lord Foundation of NC

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People: W. Krassowska Neu, B. Stone,

Collaborators: M. Lieberman (Cell Biology), D. Frazier, R. Ideker, T. Pilkington, P. Wolf

Key Publications:

W. Krassowska, Field stimulation of cardiac fibers with random spatial structure, IEEE Trans. Biomed. Eng., submitted.

B. A. Stone, M. Lieberman and W. Krassowska, Field stimulation of isolated chick heart cells: Comparison of experimental and theoretical activation thresholds, J. Cardiovasc. Electrophysiol., 10: 92-107, 1999

W. Krassowska, T. C. Pilkington and R. E. Ideker, Potential distribution in three-dimensional periodic myocardium: Part II. Application to extracellular stimulation, IEEE Trans. Biomed. Eng., 37: 267-284, 1990

D. W. Frazier, W. Krassowska, P.-S. Chen, P. D. Wolf, N. D. Danieley, W. M. Smith and R. E. Ideker, Transmural activations and stimulus potentials in three-dimensional anisotropic canine myocardium, Circ. Res., 63: 135-146, 1988

D. W. Frazier, W. Krassowska, P.-S. Chen, P. D. Wolf, E. G. Dixon, W. M. Smith and R. E. Ideker, Extracellular field required for excitation in three-dimensional anisotropic canine myocardium, Circ. Res., 63: 147-164, 1988

W. Krassowska, T. C. Pilkington and R. E. Ideker, Periodic conductivity as a mechanism for cardiac stimulation and defibrillation, IEEE Trans. Biomed. Eng., 34: 555-560, 1987

Support: NIH Grants HL54071, HL207105, HL40092, HL28429, HL33637, HL44066, HL17670 and HL 07063, NSF Grants BES-9409026 and CDR-8622201, and the Whitaker Foundation.

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People: W. Krassowska Neu

Collaborators: R. Ideker, W. Smith, P. Wolf, G. Walcott, P. Guse, C. Alferness

Key Publications:

W. Krassowska, D. J. Gauthier, and D. G. Schaeffer, Defibrillation with small shocks: Myth or reality? Phys. Rev. Lett., submitted

G. P. Walcott, R. G. Walker, A. W. Cates, W. Krassowska, W. M. Smith and R. E. Ideker, Choosing the optimal monophasic and biphasic waveforms for ventricular defibrillation, J. Cardiovasc. Electrophysiol., 6: 737-750, 1995

P. A. Guse, D. R. Rollins, W. Krassowska, P. D. Wolf, W. M. Smith and R. E. Ideker Effective defibrillation in pigs using interleaved and common phase sequential biphasic shocks, PACE, 16: 1719-1734, 1993

R. E. Ideker, P. D. Wolf, C. A. Alferness, W. Krassowska and W. M. Smith Current concepts for selecting the location, size, and shape of defibrillation electrodes, PACE, 14: 227-240, 1991

Support: NIH Grants HL40092, HL42760, HL42760, HL44066, HL28429, HL33637 and HL17670, NSF Grant NSF-9982860 and CDR-8622201, Cardiac Pacemakers Inc. and PhysioControl Corp.

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